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Bright quasar samples at high redshift are useful for investigating active galactic nuclei evolution. In this study, we describe XQz5, a sample of 83 ultraluminous quasars in the redshift range 4.5 < z < 5.3 with optical and near-infrared spectroscopic observations, with unprecedented completeness at the bright end of the quasar luminosity function. The sample is observed with the Southern Astrophysical Research Telescope, the Very Large Telescope, and the Australian National University 2.3 m Telescope, resulting in a high-quality, moderate-resolution spectral atlas of the brightest known quasars within the redshift range. We use established virial mass relations to derive the black hole masses by measuring the observed Mg ii λ2799 Å emission line and we estimate the bolometric luminosity with bolometric corrections to the ultraviolet continuum. Comparisons to literature samples show that XQz5 bridges the redshift gap between other X-shooter quasar samples, XQ-100 and XQR-30, and is a brighter sample than both. Luminosity-matched lower redshift samples host more massive black holes, which indicate that quasars at high redshift are more active than their counterparts at lower redshift, in concordance with recent literature.

 

We measure the mean free path ($\lambda _{\rm mfp,H\, \small {I}}$), photoionization rate ($\langle \Gamma _{\rm H\, \small {I}} \rangle$), and neutral fraction ($\langle f_{\rm H\, \small {I}} \rangle$) of hydrogen in 12 redshift bins at 4.85 < z < 6.05 from a large sample of moderate resolution XShooter and ESI QSO absorption spectra. The fluctuations in ionizing radiation field are modelled by post-processing simulations from the Sherwood suite using our new code ‘EXtended reionization based on the Code for Ionization and Temperature Evolution’ (ex-cite). ex-cite uses efficient Octree summation for computing intergalactic medium attenuation and can generate large number of high resolution $\Gamma _{\rm H\, \small {I}}$ fluctuation models. Our simulation with ex-cite shows remarkable agreement with simulations performed with the radiative transfer code Aton and can recover the simulated parameters within 1σ uncertainty. We measure the three parameters by forward-modelling the  Lyα forest and comparing the effective optical depth ($\tau _{\rm eff, H\, \small {I}}$) distribution in simulations and observations. The final uncertainties in our measured parameters account for the uncertainties due to thermal parameters, modelling parameters, observational systematics, and cosmic variance. Our best-fitting parameters show significant evolution with redshift such that $\lambda _{\rm mfp,H\, \small {I}}$ and $\langle f_{\rm H\, \small {I}} \rangle$ decreases and increases by a factor ∼6 and ∼104, respectively from z ∼ 5 to z ∼ 6. By comparing our $\lambda _{\rm mfp,H\, \small {I}}$, $\langle \Gamma _{\rm H\, \small {I}} \rangle$ and $\langle f_{\rm H\, \small {I}} \rangle$ evolution with that in state-of-the-art Aton radiative transfer simulations and the Thesan and CoDa-III simulations, we find that our best-fitting parameter evolution is consistent with a model in which reionization completes by z ∼ 5.2. Our best-fitting model that matches the $\tau _{\rm eff, H\, \small {I}}$ distribution also reproduces the dark gap length distribution and transmission spike height distribution suggesting robustness and accuracy of our measured parameters.

 

Proximity zones of high-redshift quasars are unique probes of their central supermassive black holes as well as the intergalactic medium (IGM) in the last stages of reionization. We present 22 new measurements of proximity zones of quasars with redshifts between 5.8 and 6.6, using the enlarged XQR-30 sample of high-resolution, high-SNR quasar spectra. The quasars in our sample have ultraviolet magnitudes of M1450 ∼ −27 and black hole masses of 109–1010 M⊙. Our inferred proximity zone sizes are 2–7 physical Mpc, with a typical uncertainty of less than 0.5 physical Mpc, which, for the first time, also includes uncertainty in the quasar continuum. We find that the correlation between proximity zone sizes and the quasar redshift, luminosity, or black hole mass, indicates a large diversity of quasar lifetimes. Two of our proximity zone sizes are exceptionally small. The spectrum of one of these quasars, with z  = 6.02, displays, unusually for this redshift, damping wing absorption without any detectable metal lines, which could potentially originate from the IGM. The other quasar has a high-ionization absorber ∼0.5 pMpc from the edge of the proximity zone. This work increases the number of proximity zone measurements available in the last stages of cosmic reionization to 87. This data will lead to better constraints on quasar lifetimes and obscuration fractions at high redshift, that in turn will help probe the seed mass and formation redshift of supermassive black holes.

 

The mean free path of ionizing photons,λ_mfp, is a critical parameter for modeling the intergalactic medium (IGM) both during and after reionization. We present direct measurements ofλ_mfpfrom QSO spectra over the redshift range 5 <z< 6, including the first measurements atz≃ 5.3 and 5.6. Our sample includes data from the XQR-30 VLT large program, as well as new Keck/ESI observations of QSOs nearz∼ 5.5, for which we also acquire new [Cii] 158μm redshifts with ALMA. By measuring the Lyman continuum transmission profile in stacked QSO spectra, we find${\lambda }_{\mathrm{mfp}}={9.33}_{-1.80}^{+2.06}$,${5.40}_{-1.40}^{+1.47}$,${3.31}_{-1.34}^{+2.74}$, and${0.81}_{-0.48}^{+0.73}$pMpc atz= 5.08, 5.31, 5.65, and 5.93, respectively. Our results demonstrate thatλ_mfpincreases steadily and rapidly with time over 5 <z< 6. Notably, we find thatλ_mfpdeviates significantly from predictions based on a fully ionized and relaxed IGM as late asz= 5.3. By comparing our results to model predictions and indirectλ_mfpconstraints based on IGM Lyαopacity, we find that the evolution ofλ_mfpis consistent with scenarios wherein the IGM is still undergoing reionization and/or retains large fluctuations in the ionizing UV background well below redshift 6.

 

In addition to the classical immunological functions such as neutralization, antibody-dependent cellular cytotoxicity, and complement activation, IgG antibodies possess a little-recognized and under-utilized effector function at mucosal surfaces: trapping pathogens in mucus. IgG can potently immobilize pathogens that otherwise readily diffuse or actively swim through mucus by forming multiple low-affinity bonds between the array of pathogen-bound antibodies and the mucin mesh. Trapping in mucus can exclude pathogens from contacting target cells, and facilitate their rapid elimination by natural mucus clearance mechanisms. Despite the fact that most infections are transmitted at mucosal surfaces, this muco-trapping effector function has only been revealed within the past decade, with the evidence to date suggesting that it is a universal effector function of IgG-Fc capable of immobilizing both viral and highly motile bacterial pathogens in all major mucosal secretions. This review provides an overview of the current evidence for Fc-mucin crosslinking as an effector function for antibodies in mucus, the mechanism by which the accumulation of weak Fc-mucin bonds by IgG bound to the surface of a pathogen can result in immobilization of antibody-pathogen complexes, and how trapping in mucus can contribute to protection against foreign pathogens. 

We search for ultraluminous Quasi-Stellar Objects (QSOs) at high redshift using photometry from the SkyMapper Southern Survey Data Release 3 (DR3), in combination with 2MASS, VHS DR6, VIKING DR5, AllWISE, and CatWISE2020, as well as parallaxes and proper motions from Gaia DR2 and eDR3. We report 142 newly discovered Southern QSOs at 3.8 < z < 5.5, of which 126 have M145 < −27 AB mag and are found in a search area of 14 486 deg2. This Southern sample, utilizing the Gaia astrometry to offset wider photometric colour criteria, achieves unprecedented completeness for an ultraluminous QSO search at high redshift. In combination with already known QSOs, we construct a sample that is >80 per cent complete for M145 < −27.33 AB mag at z = 4.7 and for M145 < −27.73 AB mag at z = 5.4. We derive the bright end of the QSO luminosity function at rest frame 145 nm for z = 4.7–5.4 and measure its slope to be β = −3.60 ± 0.37 and β = −3.38 ± 0.32 for two different estimates of the faint-end QSO density adopted from the literature. We also present the first z ∼ 5 QSO luminosity function at rest frame 300 nm.